Novel Variant of the qnrB Gene, qnrB12 , in Citrobacter werkmanii
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چکیده
منابع مشابه
Novel variant of the qnrB gene, qnrB12, in Citrobacter werkmanii.
Three epidemiologically and clonally unrelated Citrobacter werkmanii isolates of poultry origin from Germany (Table 1) were investigated for the mechanisms responsible for decreased fluoroquinolone susceptibility. The MICs, determined by broth macrodilution (10), varied between 8 and 256 g/ml for nalidixic acid and between 0.0625 and 1 g/ml for ciprofloxacin (Table 1). CIT2 was additionally res...
متن کاملNovel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii.
Resistance to quinolones in Gram-negative bacteria is usually mediated by the following: (i) chromosomal mutations that alter the target enzymes, DNA gyrase and topoisomerase IV, in their quinolone resistance-determining regions (QRDR), (ii) changes in drug entry (loss of porin channels), and (iii) the presence of plasmid-mediated quinolone resistance (PMQR) determinants [qnrA, qnrB, qnrS, qnrC...
متن کاملCitrobacter spp. as a source of qnrB Alleles.
qnrB is the most common of the five qnr families and has the greatest number of allelic variants. Almost two-thirds of the qnrB alleles have been reported in Citrobacter spp., and several were shown to be located on the chromosome. In this study, PCR was used to investigate the prevalence of plasmid-mediated quinolone resistance genes in 71 clinical isolates belonging to the Citrobacter freundi...
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15 صفحه اولHigh yield 1,3-propanediol production by rational engineering of the 3-hydroxypropionaldehyde bottleneck in Citrobacter werkmanii
BACKGROUND Imbalance in cofactors causing the accumulation of intermediates in biosynthesis pathways is a frequently occurring problem in metabolic engineering when optimizing a production pathway in a microorganism. In our previous study, a single knock-out Citrobacter werkmanii ∆dhaD was constructed for improved 1,3-propanediol (PDO) production. Instead of an enhanced PDO concentration on thi...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2008
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.01042-07